The significance of a talisman or amulet in many traditions has often been described as something to safeguard one from harm. While this is true, I believe it is important to see the Khamsa (and other such Tools) as an agent of good will. Rather than using it explicitly to protect oneself from negativity, one can focus on using it to call in what is desired for the highest good. It's important to know what we want in life as much as it is to know what we do not want; and the more we focus our attention on what truly Serves, the easier the energy and form of positivity can manifest for all.
In Ishka's The Eye of Fatima, the Star of David is inscribed within the Hand. In the Jewish tradition, the Star (or Shield) of David is an emblem of great protection. But furthermore, the star itself is a hexagram: a two-dimensional representation of the Merkabah. Merkabah literally means Chariot in the Hebrew language. It is the perfect union of polarities, of earth and sky, the Divine Feminine and Divine Masculine. The Merkabah is the vehicle of complete harmony and cooperation of opposites. The face in this drawing personifies the Divine Feminine which is coming back into power, back into balance with her masculine counterpart. Her Eye is steady and intent. She Sees through all the layers of human nature, and pierces the Heart with her gaze. She is the unfoldment of time and space, the expansion of all that is, the current of everlasting Life.